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HRID70790

反应详情

EQUATION

反应方程式

HRID 70790 的结构方程式

REACTANTS

反应物

2
结构：CO[C@]1(COCc2ccccc2)CCN(C(=O)OC(C)(C)C)C[C@H]1F
HCID71268704

1-Piperidinecarboxylic acid, 3-fluoro-4-methoxy-4-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (3R,4S)-rel-

C19H28FNO4

结构：[H][H]
HCID178418361

未命名化合物

PRODUCTS

生成物

1
结构：CO[C@]1(CO)CCN(C(=O)OC(C)(C)C)C[C@H]1F
HCID71268706

未命名化合物

收率 110.6%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[OH-].[OH-].[Pd+2]
催化剂HCID9942167

Palladium hydroxide

H2O2Pd

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

20% palladium hydroxide on carbon powder (102 mg) was suspended in a MeOH (29 ml) solution of tert-butyl rel-(3R,4S)-4-[(benzyloxy)methyl]-3-fluoro-4-methoxypiperidine-1-carboxylate (971 mg), and stirring was performed at room temperature under a flow of hydrogen gas for 4 hours. After filtration through Celite, the filtrate was concentrated to obtain tert-butyl rel-(3R,4S)-3-fluoro-4-(hydroxymethyl)-4-methoxypiperidine-1-carboxylate (800 mg).

WORKUP

后处理

  1. filtrationAfter filtration through Celite
  2. concentrationthe filtrate was concentrated