反应详情

N-[2-Bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)phenyl]-quinoline-6-carboxamide (0.73 g) was dissolved in dichloromethane (50 ml), added with 3-chloroperbenzoic acid (purity 70%, 0.48 g), and sited at room temperature for S hours. The solvent was distilled off under the reduced pressure and the residue was dissolved in ethyl acetate, Sodium hydrocarbonate solution and potassium carbonate were added thereto. After extracting the mixture twice with ethyl acetate, the organic phases were combined and washed with water, and dried over anhydrous magnesium sulfate. The drying agent (anhydrous magnesium sulfate) was filtered off and the solvent was removed by distillation under the 1.5 reduced pressure to obtain N-[2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)phenyl]quinoline-6-carboxamide-1-oxide (0.81 g, 98%).

1. customsited at room temperature for S hours
2. distillationThe solvent was distilled off under the reduced pressure
3. dissolutionthe residue was dissolved in ethyl acetate
4. additionSodium hydrocarbonate solution and potassium carbonate were added
5. extractionAfter extracting the mixture twice with ethyl acetate
6. washwashed with water
7. dry with materialdried over anhydrous magnesium sulfate
8. filtrationThe drying agent (anhydrous magnesium sulfate) was filtered off
9. customthe solvent was removed by distillation under the 1.5 reduced pressure