HCID 131733768, compound → HCID 118380273, compound

HRID 708429Notes

Reaction equation

HRID 708429 reaction equation
[CH3:1][C:2]1[N:6]=[CH:5][N:4]([CH2:7][C@@H:8]2[C@H:11]([NH:12]C(=O)OCC3C=CC=CC=3)[C:10](=[O:23])[NH:9]2)[N:3]=1>CO.[Pd]>[NH2:12][C@H:11]1[C@@H:8]([CH2:7][N:4]2[CH:5]=[N:6][C:2]([CH3:1])=[N:3]2)[NH:9][C:10]1=[O:23]

Participants

4

Reactant 1

HCID 131733768HCID 131733768, compound

Product 1

HCID 118380273HCID 118380273, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A slurry of benzyl ((2R,3S)-2-((3-methyl-1H-1,2,4-triazol-1-yl)methyl)-4-oxoazetidin-3-yl)carbamate (250 mg, 0.79 mmol) and Pd on C (10%, 100 mg) in MeOH (20 mL) was evacuated and backfilled with H2 (3×), bringing the final pressure to 35 psi. After 2 h of stirring the mixture was filtered over celite, washing with MeOH and the filtrate was concentrated in vacuo. The crude residue was used as such in the following step.

Workup

  1. filtrationwas filtered over celite
  2. washwashing with MeOH
  3. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-57eda535c5b445b59f68495b86f8664f
Source dataset
uspto-grants-2015_11
Patent number
US09174978B2

Reaction notes

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