Oxalyl chloride → 2-Methyl-1,3-oxazole-4-carbonyl chloride

HRID 708785Notes

Reaction equation

HRID 708785 reaction equation
[CH3:1][C:2]1[O:3][CH:4]=[C:5]([C:7]([OH:9])=O)[N:6]=1.C(Cl)(=O)C([Cl:13])=O>C(Cl)Cl>[CH3:1][C:2]1[O:3][CH:4]=[C:5]([C:7]([Cl:13])=[O:9])[N:6]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 5394042-Methyloxazole-4-carboxylic acid

Product 1

HCID 146590622-Methyl-1,3-oxazole-4-carbonyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirring solution of 2-methyl-oxazole-4-carboxylic acid (30 mg) in DCM (2.0 mL), oxalyl chloride (3.0 eq) was added at room temperature. The reaction mixture was stirred for 30 minutes. Solvents were evaporated and dried under vacuo to afford 2-methyl-oxazole-4-carbonyl chloride.

Workup

  1. customSolvents were evaporated
  2. customdried under vacuo

Sources & evidence

ORD record
ord-c48f5be5f8a243ffb85313177851806e
Source dataset
uspto-grants-2015_11
Patent number
US09175003B2

Reaction notes

Loading…