Hydrochloric Acid → HCID 118101206, compound

Participants

Reaction Steps

To a solution of 8A (1 g, 2.92 mmol) in ethyl acetate (10 ml) was added 4N HCl (29.2 ml, 117 mmol) and the mixture was stirred at r.t. for 4 h. Solvent was removed under reduced pressure to yield 8B (920 mg, 2.92 mmol, 100% yield) as a yellow solid. 1H NMR (500 MHz, methanol-d3) δ ppm 1.27 (d, J=6.60 Hz, 6H) 3.26-3.41 (m, 1H) 3.66 (s, 3H) 4.28 (s, 2H) 6.79-6.91 (m, 2H) 7.68 (d, J=8.80 Hz, 1H).

Provenance & Evidence