Hydrochloric Acid → HCID 118101206, compound

HRID 708830Notes

Reaction equation

HRID 708830 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([S:18]([CH:21]([CH3:23])[CH3:22])(=[O:20])=[O:19])=[C:6]([CH:17]=1)[CH2:7][N:8](C)[C:9](=O)OC(C)(C)C.Cl>C(OCC)(=O)C>[CH:21]([S:18]([C:5]1[CH:4]=[CH:3][C:2]([NH2:1])=[CH:17][C:6]=1[CH2:7][NH:8][CH3:9])(=[O:19])=[O:20])([CH3:23])[CH3:22]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59315233HCID 59315233, compound

Product 1

HCID 118101206HCID 118101206, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 8A (1 g, 2.92 mmol) in ethyl acetate (10 ml) was added 4N HCl (29.2 ml, 117 mmol) and the mixture was stirred at r.t. for 4 h. Solvent was removed under reduced pressure to yield 8B (920 mg, 2.92 mmol, 100% yield) as a yellow solid. 1H NMR (500 MHz, methanol-d3) δ ppm 1.27 (d, J=6.60 Hz, 6H) 3.26-3.41 (m, 1H) 3.66 (s, 3H) 4.28 (s, 2H) 6.79-6.91 (m, 2H) 7.68 (d, J=8.80 Hz, 1H).

Workup

  1. customSolvent was removed under reduced pressure

Sources & evidence

ORD record
ord-821e63e165c843f7ae86db62d63c3d07
Source dataset
uspto-grants-2015_11
Patent number
US09174974B2

Reaction notes

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