Hydrochloric Acid → HCID 118092905, compound

HRID 708842Notes

Reaction equation

HRID 708842 reaction equation
[ClH:1].C(OC([NH:9][C:10]1[CH:11]=[CH:12][C:13]([P:26]([O:31][CH2:32][CH3:33])([O:28][CH2:29][CH3:30])=[O:27])=[C:14]([CH:25]=1)[CH2:15][N:16](C)[C:17](=O)OC(C)(C)C)=O)(C)(C)C>O1CCOCC1>[ClH:1].[CH2:32]([O:31][P:26]([C:13]1[CH:12]=[CH:11][C:10]([NH2:9])=[CH:25][C:14]=1[CH2:15][NH:16][CH3:17])(=[O:27])[O:28][CH2:29][CH3:30])[CH3:33]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118101228HCID 118101228, compound

Product 1

HCID 118092905HCID 118092905, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

HCl in dioxane (4.0 M, 1 mL) was added to 12C (100 mg, 0.212 mmol) and stirred at rt for 1 h. The reaction mixture was concentrated to yield 12D (70 mg, 0.203 mmol, 96% yield) as a yellow solid.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-4721381272f540fea76f0c2e2ebba597
Source dataset
uspto-grants-2015_11
Patent number
US09174974B2

Reaction notes

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