4-(Chloromethyl)-2-methyl-1,3-oxazole → 3-(Methoxymethoxy)-1-(methoxymethyl)-5-{[(2-methyl-1,3-oxazol-4-yl)methyl]sulfanyl}pyridin-2(1H)-one

HRID 709036Notes

Reaction equation

HRID 709036 reaction equation
C(C1C=[CH:23][C:6]([CH2:7][S:8][C:9]2[CH:10]=[C:11]([O:19][CH2:20][O:21][CH3:22])[C:12](=[O:18])[N:13]([CH2:15][O:16][CH3:17])[CH:14]=2)=CC=1)C.[CH3:25][C:26]1[O:27]C=C(CCl)[N:30]=1>>[CH3:22][O:21][CH2:20][O:19][C:11]1[C:12](=[O:18])[N:13]([CH2:15][O:16][CH3:17])[CH:14]=[C:9]([S:8][CH2:7][C:6]2[N:30]=[C:26]([CH3:25])[O:27][CH:23]=2)[CH:10]=1

Participants

3

Reactant 2

HCID 216983214-(Chloromethyl)-2-methyl-1,3-oxazoleHCID 867315275-[(4-ethylbenzyl)sulfanyl]-3-(methoxymethoxy)-1-(methoxymethyl)pyridin-2(1H)-one2×

Product 1

HCID 867315313-(Methoxymethoxy)-1-(methoxymethyl)-5-{[(2-methyl-1,3-oxazol-4-yl)methyl]sulfanyl}pyridin-2(1H)-one

Procedure

Prepared as described for 5-[(4-ethylbenzyl)sulfanyl]-3-(methoxymethoxy)-1-(methoxymethyl)pyridin-2(1H)-one (Intermediate 17) but using 2-methyl-4-chloromethyl-1,3-oxazole instead of 1-(chloromethyl)-4-ethylbenzene.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-fc5f14cee9d54edab19933bd7ca250c7
Source dataset
uspto-grants-2015_11
Patent number
US09180122B2

Reaction notes

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