5-Chloro-2-(chloromethyl)pyridine → 5-{[(5-Chloropyridin-2-yl)methyl]sulfanyl}-3-(methoxymethoxy)-1-(methoxymethyl)pyridin-2(1H)-one

HRID 709039Notes

Reaction equation

HRID 709039 reaction equation
C(C1C=CC(C[S:8][C:9]2[CH:10]=[C:11]([O:19][CH2:20][O:21][CH3:22])[C:12](=[O:18])[N:13]([CH2:15][O:16][CH3:17])[CH:14]=2)=CC=1)C.Cl[CH2:26][C:27]1[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][N:28]=1>>[Cl:33][C:30]1[CH:31]=[CH:32][C:27]([CH2:26][S:8][C:9]2[CH:10]=[C:11]([O:19][CH2:20][O:21][CH3:22])[C:12](=[O:18])[N:13]([CH2:15][O:16][CH3:17])[CH:14]=2)=[N:28][CH:29]=1

Participants

3

Reactant 2

HCID 145171515-Chloro-2-(chloromethyl)pyridineHCID 867315275-[(4-ethylbenzyl)sulfanyl]-3-(methoxymethoxy)-1-(methoxymethyl)pyridin-2(1H)-one2×

Product 1

HCID 867315345-{[(5-Chloropyridin-2-yl)methyl]sulfanyl}-3-(methoxymethoxy)-1-(methoxymethyl)pyridin-2(1H)-one

Procedure

Prepared as described for 5-[(4-ethylbenzyl)sulfanyl]-3-(methoxymethoxy)-1-(methoxymethyl)pyridin-2(1H)-one (Intermediate 17) but using 2-chloromethyl-5-chloropyridine instead of 1-(chloromethyl)-4-ethylbenzene.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e7287ba653534dd3afc3bfb319fb587d
Source dataset
uspto-grants-2015_11
Patent number
US09180122B2

Reaction notes

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