3-Iodotoluene → 3-hydroxy-5-(2-methylphenethyl)pyridin-2(1H)-one

HRID 709049Notes

Reaction equation

HRID 709049 reaction equation
C[O:2][C:3]1[C:8]([O:9]C)=[CH:7][C:6]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])=[CH:5][N:4]=1.IC1C=CC=C(C)C=1>>[OH:9][C:8]1[C:3](=[O:2])[NH:4][CH:5]=[C:6]([CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])[CH:7]=1

Participants

3

Reactant 2

HCID 122683-IodotolueneHCID 711862092,3-Dimethoxy-5-[(2-methylphenyl)ethynyl]pyridine2×

Product 1

HCID 711871703-hydroxy-5-(2-methylphenethyl)pyridin-2(1H)-one

Procedure

Prepared as described for 2,3-dimethoxy-5-[(2-methylphenyl)ethynyl]pyridine (Intermediate 33) but using 1-iodo-3-methylbenzene instead of 1-iodo-2-methylbenzene.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-13e57c047eee4688be8fdd41aa1f07b2
Source dataset
uspto-grants-2015_11
Patent number
US09180122B2

Reaction notes

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