5-[(4-Fluorophenyl)ethynyl]-2,3-dimethoxypyridine → 5-[2-(4-Fluorophenyl)ethyl]-3-hydroxypyridin-2(1H)-one

HRID 709084Notes

Reaction equation

HRID 709084 reaction equation
OC1C(=O)NC=C(CCC2C=CC=CC=2C)C=1.[F:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]#[C:26][C:27]2[CH:28]=[C:29]([O:35]C)[C:30]([O:33]C)=[N:31][CH:32]=2)=[CH:21][CH:20]=1>>[F:18][C:19]1[CH:20]=[CH:21][C:22]([CH2:25][CH2:26][C:27]2[CH:28]=[C:29]([OH:35])[C:30](=[O:33])[NH:31][CH:32]=2)=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 711864625-[(4-Fluorophenyl)ethynyl]-2,3-dimethoxypyridine2×HCID 711871703-hydroxy-5-(2-methylphenethyl)pyridin-2(1H)-one

Product 1

HCID 711862955-[2-(4-Fluorophenyl)ethyl]-3-hydroxypyridin-2(1H)-one

Procedure

Prepared as described for 3-hydroxy-5-(2-methylphenethyl)pyridin-2(1H)-one (Example 27) from 5-[(4-fluorophenyl)ethynyl]-2,3-dimethoxypyridine (Intermediate 36).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-6b691d312d224a4ab07058abf3805dd7
Source dataset
uspto-grants-2015_11
Patent number
US09180122B2

Reaction notes

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