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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 709084Generated: October 29, 2026

5-[(4-Fluorophenyl)ethynyl]-2,3-dimethoxypyridine → 5-[2-(4-Fluorophenyl)ethyl]-3-hydroxypyridin-2(1H)-one

https://huagongshe.com/reaction/709084

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-[(4-Fluorophenyl)ethynyl]-2,3-dimethoxypyridineHCID 71186462—
Reactant3-hydroxy-5-(2-methylphenethyl)pyridin-2(1H)-oneHCID 71187170—
Product5-[2-(4-Fluorophenyl)ethyl]-3-hydroxypyridin-2(1H)-oneHCID 71186295—

Reaction Steps

Prepared as described for 3-hydroxy-5-(2-methylphenethyl)pyridin-2(1H)-one (Example 27) from 5-[(4-fluorophenyl)ethynyl]-2,3-dimethoxypyridine (Intermediate 36).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09180122B2
Source datasetuspto-grants-2015_11
ORD IDord-6b691d312d224a4ab07058abf3805dd7
Source noteuspto-grants-2015_11