反应详情

To a solution of 5-[(3-fluorobenzyl)sulfanyl]-2,3-bis(methoxymethoxy)pyridine (Intermediate 43; 690 mg, 2.03 mmol) in dioxane (4 ml) was added a solution of hydrogen chloride in dioxane (4.0 M; 2.54 ml, 10.17 mmol) and the reaction stirred for 16 hours before being concentrated in vacuo. The crude product was recrystallised from ethanol and water to yield 5-[(3-fluorobenzyl)sulfanyl]-3-hydroxypyridin-2(1H)-one as a pale grey solid (309 mg, 61%).

1. concentrationbefore being concentrated in vacuo
2. customThe crude product was recrystallised from ethanol and water