HCID 58012296, compound → HCID 58011728, compound

HRID 709123Notes

Reaction equation

HRID 709123 reaction equation
C(OC([NH:11][CH2:12][CH:13]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:25]([F:28])([F:27])[F:26])[C:14]([O:16][CH2:17][CH3:18])=[O:15])=O)C1C=CC=CC=1>C(O)C.[Pd]>[NH2:11][CH2:12][CH:13]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:25]([F:26])([F:27])[F:28])[C:14]([O:16][CH2:17][CH3:18])=[O:15]

Participants

4

Reactant 1

HCID 58012296HCID 58012296, compound

Product 1

HCID 58011728HCID 58011728, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1.035 g (2.54 mmol) of ethyl 3-{[(benzyloxy)carbonyl]amino}-2-[2-(trifluoromethyl)phenyl]propanoate [for the preparation see Example 193A in WO 2007/134862] were dissolved in 24 ml of ethanol and hydrogenated in the presence of 100 mg of 10% palladium on carbon for 3 h at atmospheric pressure. The catalyst was then filtered off and the filtrate was freed from the solvent on a rotary evaporator. The residue corresponded to the title compound.

Workup

  1. filtrationThe catalyst was then filtered off
  2. customthe filtrate was freed from the solvent on a rotary evaporator

Sources & evidence

ORD record
ord-96d2772fb3d74bc9a6280f7cdc63f1ec
Source dataset
uspto-grants-2015_11
Patent number
US09180120B2

Reaction notes

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