Trifluoromethanesulfonic anhydride → Methyl {3-(4-chlorophenyl)-5-oxo-4-[(1E)-3,3,3-trifluoroprop-1-en-1-yl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetate

Participants

Reaction Steps

At RT, 280 mg (0.74 mmol) of the compound of Example 7A together with 108 mg (0.89 mmol) of 4-N,N-dimethylaminopyridine were initially charged in 5.3 ml of pyridine, 0.31 ml (1.84 mmol) of trifluoromethanesulphonic anhydride were added a little at a time and the mixture was stirred for 12 h. The pyridine was then removed on a rotary evaporator. The residue was taken up in acetonitrile and 1 N hydrochloric acid and purified by preparative HLPC [Method 9]. This gave 230 mg (86% of theory) of the title compound.

Provenance & Evidence