反应详情

温度

50 °C

At 50° C., 3.1 g (17.55 mmol) of 5-chlorothiophene-2-carbohydrazide were substantially suspended in 30 ml of dry THF. 1.81 g (17.90 mmol) of 1-isocyanato-2-methoxyethane dissolved in 30 ml of THF were then added dropwise. The mixture was stirred at 50° C. for 2.5 h. After cooling to RT, the solvent was removed on a rotary evaporator and the residue was triturated with diethyl ether. The crystals were filtered off with suction, washed with diethyl ether and dried under high vacuum. This gave 4.87 g (100% of theory) of the title compound.

1. customAt 50° C.
2. additionwere then added dropwise
3. temperatureAfter cooling to RT
4. customthe solvent was removed on a rotary evaporator
5. customthe residue was triturated with diethyl ether
6. filtrationThe crystals were filtered off with suction
7. washwashed with diethyl ether
8. customdried under high vacuum