反应详情

温度

80 °C

2.4 g (9.24 mmol) of the compound of Example 50A and 2.55 g (18.48 mmol) of potassium carbonate were suspended in 48 ml of acetonitrile. 1.08 ml (10.17 mmol) of ethyl chloroacetate were then added, and the mixture was heated under reflux at 80° C. for 4.5 h. Another 113 mg (0.92 mmol) of ethyl chloroacetate were then added, and the mixture was stirred at 80° C. for a further 2 h. The suspension was then filtered through a layer of silica gel and washed with ethyl acetate, the filtrate was evaporated on a rotary evaporator and the residue was dried under high vacuum. This gave 3.24 g (100% of theory) of the title compound.

1. temperaturethe mixture was heated
2. filtrationThe suspension was then filtered through a layer of silica gel
3. washwashed with ethyl acetate
4. customthe filtrate was evaporated on a rotary evaporator
5. customthe residue was dried under high vacuum