HRID709167

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID43099850

未命名化合物

HCID59536891

未命名化合物

PRODUCTS

生成物

结构：COCCn1c(-c2ccc(Cl)s2)nn(CC(=O)NCC(NC(=O)OC(C)(C)C)c2ccccc2C(F)(F)F)c1=O

HCID56848685

未命名化合物

PROCEDURE

实验过程

Analogously to the procedure of Example 63, 47 mg (146 μmol) of the compound of Example 52A were reacted with 49 mg (161 μmol) of tert-butyl {2-amino-1-[2-(trifluoromethyl)phenyl]-ethyl}carbamate. This gave 60 mg (68% of theory) of the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d341e92629d840a7adf4aca9523ed0c2
来源数据集: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09180120B2
来源说明: uspto-grants-2015_11

反应 SMILES

[Cl:1][C:2]1[S:6][C:5]([C:7]2[N:11]([CH2:12][CH2:13][O:14][CH3:15])[C:10](=[O:16])[N:9]([CH2:17][C:18]([OH:20])=O)[N:8]=2)=[CH:4][CH:3]=1.[NH2:21][CH2:22][CH:23]([NH:34][C:35](=[O:41])[O:36][C:37]([CH3:40])([CH3:39])[CH3:38])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[C:30]([F:33])([F:32])[F:31]>>[Cl:1][C:2]1[S:6][C:5]([C:7]2[N:11]([CH2:12][CH2:13][O:14][CH3:15])[C:10](=[O:16])[N:9]([CH2:17][C:18]([NH:21][CH2:22][CH:23]([NH:34][C:35](=[O:41])[O:36][C:37]([CH3:39])([CH3:38])[CH3:40])[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[C:30]([F:33])([F:32])[F:31])=[O:20])[N:8]=2)=[CH:4][CH:3]=1