tert-Butyl {2-amino-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate → tert-Butyl {2-({[3-(5-chloro-2-thienyl)-4-(2-methoxyethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}amino)-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate

Participants

Role	Name	HCID	Charge
Reactant	tert-Butyl {2-amino-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate	HCID 43099850	—
Reactant	[3-(5-Chloro-2-thienyl)-4-(2-methoxyethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetic acid	HCID 59536891	—
Product	tert-Butyl {2-({[3-(5-chloro-2-thienyl)-4-(2-methoxyethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}amino)-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate	HCID 56848685	—

Reaction Steps

Analogously to the procedure of Example 63, 47 mg (146 μmol) of the compound of Example 52A were reacted with 49 mg (161 μmol) of tert-butyl {2-amino-1-[2-(trifluoromethyl)phenyl]-ethyl}carbamate. This gave 60 mg (68% of theory) of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09180120B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-d341e92629d840a7adf4aca9523ed0c2
Source note	uspto-grants-2015_11