4-Methylbenzylamine → HCID 523206, compound

HRID 709341Notes

Reaction equation

HRID 709341 reaction equation
[CH3:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1>[Pd].CC#N>[CH3:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH:7][CH2:1][C:2]2[CH:9]=[CH:8][C:5]([CH3:6])=[CH:4][CH:3]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 660354-Methylbenzylamine

Product 1

HCID 523206HCID 523206, compoundYield 82%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 6342AcetonitrileSolvent

Conditions

Temperature
90 °C

Procedure

4-Methylbenzylamine (0.5 mmol) was also heated with catalyst Pd@ba-GO (10 mg) and solvent CH3CN (0.2 mL) at 90° C. in a flask open to air for 6 hours, and then stirred also at 90° C. under H2 gas (1 atm) for 8 hours to obtain di-(4-methylbenzyl)amine. Again, an unexpectedly high yield of 82% was achieved.

Sources & evidence

ORD record
ord-f4eb36fc90ee4560b2c729e81e8b1ad6
Source dataset
uspto-grants-2015_11
Patent number
US09180442B2

Reaction notes

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