反应详情

温度

65 °C

5 mL methanesulfonic acid was heated to 50° C. and slowly added to oximino acetanilide in batches, with the temperature being maintained at 60-70° C. After feeding, the temperature was raised to 70-80° C., and the reaction was carried out for 15 min. The reaction was finished by TLC detection. The reaction solution was poured into a crushed ice, and a red solid was precipitated. After placing at low temperature (0° C.) for 10 min, the red solid was filtered and dried to give crude isatin.

1. temperaturethe temperature was raised to 70-80° C.
2. customa red solid was precipitated
3. waitAfter placing at low temperature (0° C.) for 10 min
4. filtrationthe red solid was filtered
5. customdried