反应详情

To a suspension of lithium aluminum hydride (250 mg) in diethyl ether (5.0 mL) was added a solution of methyl 5-(2-fluoro-5-methoxyphenyl)-6-isobutoxypicolinate (594 mg) in diethyl ether (2.0 mL) at 0° C., and the mixture was stirred for 1 hr. Water and aqueous sodium hydroxide solution were added to the reaction mixture at 0° C., and the mixture was extracted with ethyl acetate. The extract was washed with water and saturated brine, and dried over anhydrous magnesium sulfate.

1. extractionthe mixture was extracted with ethyl acetate
2. washThe extract was washed with water and saturated brine
3. dry with materialdried over anhydrous magnesium sulfate