Water → (5-(2-Fluoro-5-methoxyphenyl)-6-isobutoxypyridin-2-yl)methanol

Participants

Reaction Steps

To a suspension of lithium aluminum hydride (250 mg) in diethyl ether (5.0 mL) was added a solution of methyl 5-(2-fluoro-5-methoxyphenyl)-6-isobutoxypicolinate (594 mg) in diethyl ether (2.0 mL) at 0° C., and the mixture was stirred for 1 hr. Water and aqueous sodium hydroxide solution were added to the reaction mixture at 0° C., and the mixture was extracted with ethyl acetate. The extract was washed with water and saturated brine, and dried over anhydrous magnesium sulfate.

Provenance & Evidence