反应详情

温度

60 °C

To a solution of 5-(benzyloxy)-2-methylbenzaldehyde (250 mg) in toluene (20 mL) was added ethyl (triphenylphosphoranylidene)acetate (379 mg), and the mixture was stirred at 60° C. for 15 hr. The reaction mixture was concentrated, diethyl ether was added, and the insoluble material was filtered off. The filtrate was concentrated, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (200 mg) as a yellow oil.

1. concentrationThe reaction mixture was concentrated
2. additiondiethyl ether was added
3. filtrationthe insoluble material was filtered off
4. concentrationThe filtrate was concentrated
5. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)