Sodium Methoxide → HCID 117760086, compound

HRID 709727Notes

Reaction equation

HRID 709727 reaction equation
[CH3:1][C:2]([CH3:34])([CH3:33])[CH2:3][C:4]1[N:9]=[C:8]([CH2:10][O:11][C:12]2[CH:13]=[C:14]([CH2:19][CH2:20][C:21]([OH:23])=[O:22])[CH:15]=[C:16]([CH3:18])[CH:17]=2)[CH:7]=[CH:6][C:5]=1[C:24]1[CH:29]=[C:28]([O:30][CH3:31])[CH:27]=[CH:26][C:25]=1[F:32].C[O-].[Na+:37]>CO>[CH3:1][C:2]([CH3:34])([CH3:33])[CH2:3][C:4]1[N:9]=[C:8]([CH2:10][O:11][C:12]2[CH:13]=[C:14]([CH2:19][CH2:20][C:21]([O-:23])=[O:22])[CH:15]=[C:16]([CH3:18])[CH:17]=2)[CH:7]=[CH:6][C:5]=1[C:24]1[CH:29]=[C:28]([O:30][CH3:31])[CH:27]=[CH:26][C:25]=1[F:32].[Na+:37]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 117760087HCID 117760087, compound

Product 1

HCID 117760086HCID 117760086, compoundYield 56.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 3-(3-((6-(2,2-dimethylpropyl)-5-(2-fluoro-5-methoxyphenyl)pyridin-2-yl)methoxy)-5-methylphenyl)propanoic acid (259 mg) in methanol (5.0 mL) was added sodium methoxide (29 mg) at room temperature, and the mixture was stirred for 1 hr. The reaction mixture was concentrated under reduced pressure. The residue was washed with hexane, and dried to give the title compound (147 mg) as a white solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washThe residue was washed with hexane
  3. customdried

Sources & evidence

ORD record
ord-ea4f58dd2e6d4533a74394e3424c2495
Source dataset
uspto-grants-2015_11
Patent number
US09181186B2

Reaction notes

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