反应详情

To a solution of ethyl 3-cyclopropyl-3-(2-methoxypyridin-4-yl)acrylate in acetic acid (100 mL) was added a zinc powder (16.3 g), and the mixture was stirred at room temperature for 5 min. The reaction mixture was filtered, and the solvent in the filtrate was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to give the title compound (4.17 g) as a pale-yellow oil.

1. filtrationThe reaction mixture was filtered
2. customthe solvent in the filtrate was evaporated under reduced pressure
3. customThe residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane)