Ethyl 3-cyclopropyl-3-(2-methoxypyridin-4-yl)acrylate → Ethyl 3-cyclopropyl-3-(2-methoxypyridin-4-yl)propanoate

Participants

Reaction Steps

To a solution of ethyl 3-cyclopropyl-3-(2-methoxypyridin-4-yl)acrylate in acetic acid (100 mL) was added a zinc powder (16.3 g), and the mixture was stirred at room temperature for 5 min. The reaction mixture was filtered, and the solvent in the filtrate was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to give the title compound (4.17 g) as a pale-yellow oil.

Provenance & Evidence