反应详情

A mixture of 2-(2-fluoro-5-methoxyphenyl)-3-isobutoxy-5-(methoxycarbonyl)pyridine 1-oxide (600 mg) and phosphoryl chloride (5.0 mL) was heated under reflux for 1 hr. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (315 mg) as a pale-yellow oil.

1. temperaturewas heated
2. temperatureunder reflux for 1 hr
3. customThe solvent was evaporated under reduced pressure
4. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)