Hydrochloric Acid → HCID 178508813, compound

HRID 709942Notes

Reaction equation

HRID 709942 reaction equation
C[O:2][C:3]1[N:8]=[CH:7][N:6]=[C:5]([NH2:9])[C:4]=1[C:10]([F:13])([F:12])[F:11].Cl>O1CCOCC1>[NH2:9][C:5]1[N:6]=[CH:7][N:8]=[C:3]([OH:2])[C:4]=1[C:10]([F:13])([F:12])[F:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 666076446-methoxy-5-(trifluoromethyl)-4-Pyrimidinamine

Product 1

HCID 178508813HCID 178508813, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
90 °C

Procedure

To a solution of 6-methoxy-5-(trifluoromethyl)pyrimidin-4-amine (N-3) (420 mg, 2.18 mmol) in 1,4-dioxane (10 mL), concentrated HCl (1.81 mL, 21.8 mmol) is added and the resulting mixture is stirred at 90° C. for 3 h. The mixture is allowed to cool to RT and then concentrated in vacuo to afford the product, 6-amino-5-(trifluoromethyl)pyrimidin-4-ol (N-4) as yellowish solid.

Workup

  1. temperatureto cool to RT
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-93cef1c247d94ad1acc7bf078dd75114
Source dataset
uspto-grants-2015_11
Patent number
US09181221B2

Reaction notes

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