反应详情

温度

60 °C

A solution of 5-bromo-2-chloro-4-methoxypyrimidine (0.6 g, 2.69 mmol) in THF (10 mL) was treated with ethylamine (2.0M in THF, 6.71 mL, 13.43 mmol) was heated at 60° C. for 1 h, cooled to RT and diluted with water. The mixture was extracted with EtOAc (2×) and the combined organics were washed with brine, dried over Na2SO4, concentrated to dryness and purified by column chromatography (EtOAc/Hex) to afford 5-bromo-N-ethyl-4-methoxypyrimidin-2-amine as a white solid (0.54 g, 87%). MS (ESI) m/z: 232.03 (M+H+).

1. temperaturecooled to RT
2. extractionThe mixture was extracted with EtOAc (2×)
3. washthe combined organics were washed with brine
4. dry with materialdried over Na2SO4
5. concentrationconcentrated to dryness
6. custompurified by column chromatography (EtOAc/Hex)