Hydrazine hydrate (1:1) → HCID 67188247, compound

HRID 710026Notes

Reaction equation

HRID 710026 reaction equation
CC1CC[N:4]([CH2:7][CH2:8][CH2:9][N:10]2[C:18](=[O:19])[C:17]3[C:12](=CC=CC=3)[C:11]2=O)C1=O.O.NN.[CH2:25]1COCC1.CO>>[NH2:4][CH2:7][CH2:8][CH2:9][N:10]1[CH:11]([CH3:25])[CH2:12][CH2:17][C:18]1=[O:19]

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 21899815MeOH tetrahydrofuranHCID 71224527HCID 71224527, compound

Product 1

HCID 67188247HCID 67188247, compoundYield 45%

Conditions

Temperature
50 °C

Procedure

2-[3-(3-Methyl-2-oxo-pyrrolidin-1-yl)-propyl]-isoindole-1,3-dione (0.5 g, 1.74 mmol) was taken in a mixture of THF/MeOH (3.0 mL/3.0 mL). Hydrazine hydrate (0.44 g, 8.7 mmol) was added to this and the reaction was stirred at 50° C. for 16 h. The precipitate was filtered and the filtrate was concentrated to give the product 1-(3-amino-propyl)-5-methyl-pyrrolidin-2-one (0.12 g, 45%).

Workup

  1. filtrationThe precipitate was filtered
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-9485c5215d484d2396d19172b0897742
Source dataset
uspto-grants-2015_11
Patent number
US09181226B2

Reaction notes

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