Triethylamine → HCID 86706749, compound

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	Ethyl Acetate	HCID 8857	—
Reactant	Methanesulfonyl chloride	HCID 31297	—
Reactant	(S)-2,2-Difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)-1-(2-(5-(hydroxymethyl)isoxazol-3-yl)pyrrolidin-1-yl)ethanone	HCID 86706747	—
Solvent	Water	HCID 962	—
Product	HCID 86706749	HCID 86706749	—

Reaction Steps

To an AcOEt (3 mL) solution of the compound (45 mg) obtained in Example 3-(4) and Et3N (31 μL), MsCl (13 μL) was added at 0° C. and after stirring the mixture for 30 minutes, MsCl (13 μL) was added and the mixture was stirred at 0° C. for 30 minutes, followed by addition of Et3N (31 μL) and stirring at 0° C. for 2.5 hours. The reaction mixture was added to water (50 mL) and the organic layer extracted with AcOEt (50 mL) was dried (MgSO4), filtered and concentrated to give the titled compound (58 mg, colorless oil.)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09181229B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-3eb44b70f7854e7081166ab2b5d42f8f
Source note	uspto-grants-2015_11