反应详情

To an AcOEt (3 mL) solution of the compound (45 mg) obtained in Example 3-(4) and Et3N (31 μL), MsCl (13 μL) was added at 0° C. and after stirring the mixture for 30 minutes, MsCl (13 μL) was added and the mixture was stirred at 0° C. for 30 minutes, followed by addition of Et3N (31 μL) and stirring at 0° C. for 2.5 hours. The reaction mixture was added to water (50 mL) and the organic layer extracted with AcOEt (50 mL) was dried (MgSO4), filtered and concentrated to give the titled compound (58 mg, colorless oil.)

1. stirringthe mixture was stirred at 0° C. for 30 minutes
2. stirringstirring at 0° C. for 2.5 hours
3. extractionthe organic layer extracted with AcOEt (50 mL)
4. dry with materialwas dried (MgSO4)
5. filtrationfiltered
6. concentrationconcentrated