HRID710045

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)CC(C)(C)CC(O)(C(F)(F)C(=O)N2CCC[C@H]2c2cc(CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)on2)C1

HCID86706748

未命名化合物

结构：CC1(C)CC(C)(C)CC(O)(C(F)(F)C(=O)N2CCC[C@H]2c2nnc(CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)o2)C1

HCID86706758

未命名化合物

PRODUCTS

生成物

结构：CC1(C)CC(C)(C)CC(O)(C(F)(F)C(=O)N2CCC[C@H]2c2nnc(CO)o2)C1

HCID86706757

未命名化合物

收率 86.7%

PROCEDURE

实验过程

The procedure of Example 3-(4) was repeated, except that the compound obtained in Example 3-(3) was replaced by the compound (1.378 g) obtained in Example 9-(4); this gave the titled compound (750 mg, colorless solid.)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-73472313bac244b282f088d44ff18315
来源数据集: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09181229B2
来源说明: uspto-grants-2015_11

反应 SMILES

[Si](OCC1ON=C([C@@H]2CCCN2C(=O)C(F)(F)C2(O)CC(C)(C)CC(C)(C)C2)C=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1.[Si]([O:63][CH2:64][C:65]1[O:69][C:68]([C@@H:70]2[CH2:74][CH2:73][CH2:72][N:71]2[C:75](=[O:90])[C:76]([F:89])([F:88])[C:77]2([OH:87])[CH2:82][C:81]([CH3:84])([CH3:83])[CH2:80][C:79]([CH3:86])([CH3:85])[CH2:78]2)=[N:67][N:66]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>>[F:89][C:76]([F:88])([C:77]1([OH:87])[CH2:78][C:79]([CH3:86])([CH3:85])[CH2:80][C:81]([CH3:84])([CH3:83])[CH2:82]1)[C:75]([N:71]1[CH2:72][CH2:73][CH2:74][C@H:70]1[C:68]1[O:69][C:65]([CH2:64][OH:63])=[N:66][N:67]=1)=[O:90]