HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-1-(2-(5-(((tert-Butyldiphenylsilyl)oxy)methyl)isoxazol-3-yl)pyrrolidin-1-yl)-2,2-difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)ethanone → (S)-2,2-Difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)-1-(2-(5-(hydroxymethy)-1,3,4-oxadiazol-2-yl)pyrrolidin-1-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-1-(2-(5-(((tert-Butyldiphenylsilyl)oxy)methyl)isoxazol-3-yl)pyrrolidin-1-yl)-2,2-difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)ethanone | HCID 86706748 | — |
| Reactant | (S)-1-(2-(5-(((tert-Butyldiphenylsilyl)oxy)methyl)-1,3,4-oxadiazol-2-yl)pyrrolidin-1-yl)-2,2-difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)ethanone | HCID 86706758 | — |
| Product | (S)-2,2-Difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)-1-(2-(5-(hydroxymethy)-1,3,4-oxadiazol-2-yl)pyrrolidin-1-yl)ethanone | HCID 86706757 | 86.7% |
Reaction Steps
The procedure of Example 3-(4) was repeated, except that the compound obtained in Example 3-(3) was replaced by the compound (1.378 g) obtained in Example 9-(4); this gave the titled compound (750 mg, colorless solid.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181229B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-73472313bac244b282f088d44ff18315 |
| Source note | uspto-grants-2015_11 |