HCID 86706749, compound → (S)-1-(2-(5-((Dimethylamino)methyl)-1,3,4-oxadiazol-2-yl)pyrrolidin-1-yl)-2,2-difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)ethanone

HRID 710047Notes

Reaction equation

HRID 710047 reaction equation
CS(OCC1O[N:10]=[C:9]([C@@H:12]2[CH2:16][CH2:15][CH2:14][N:13]2[C:17](=[O:32])[C:18]([F:31])([F:30])[C:19]2([OH:29])[CH2:24][C:23]([CH3:26])([CH3:25])[CH2:22][C:21]([CH3:28])([CH3:27])[CH2:20]2)C=1)(=O)=O.CS(OCC1[O:40][C:41]([C@@H:44]2CC[CH2:46][N:45]2[C:49](=O)C(F)(F)C2(O)CC(C)(C)CC(C)(C)C2)=[N:42]N=1)(=O)=O>>[CH3:46][N:45]([CH2:44][C:41]1[O:40][C:9]([C@@H:12]2[CH2:16][CH2:15][CH2:14][N:13]2[C:17](=[O:32])[C:18]([F:31])([F:30])[C:19]2([OH:29])[CH2:20][C:21]([CH3:28])([CH3:27])[CH2:22][C:23]([CH3:26])([CH3:25])[CH2:24]2)=[N:10][N:42]=1)[CH3:49]

Participants

3

Reactant 2

HCID 86706749HCID 86706749, compoundHCID 86706759(S)-(5-(1-(2,2-Difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)acetyl)pyrrolidin-2-yl)-1,3,4-oxadiazol-2-yl)methyl methanesulfonate

Product 1

HCID 86706760(S)-1-(2-(5-((Dimethylamino)methyl)-1,3,4-oxadiazol-2-yl)pyrrolidin-1-yl)-2,2-difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)ethanone

Procedure

The procedure of Example 6 was repeated, except that the compound obtained in Example 3-(5) was replaced by the compound obtained in Example 9-(6); this gave the titled compound.

Sources & evidence

ORD record
ord-3bf47a1fa0be4c668eba9c32286af543
Source dataset
uspto-grants-2015_11
Patent number
US09181229B2

Reaction notes

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