HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-(3-(1-(2,2-Difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)acetyl)pyrrolidin-2-yl)isoxazol-5-yl)methyl methanesulfonate → (S)-1-(2-(5-((Dimethylamino)methyl)-1,3,4-oxadiazol-2-yl)pyrrolidin-1-yl)-2,2-difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-(3-(1-(2,2-Difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)acetyl)pyrrolidin-2-yl)isoxazol-5-yl)methyl methanesulfonate | HCID 86706749 | — |
| Reactant | (S)-(5-(1-(2,2-Difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)acetyl)pyrrolidin-2-yl)-1,3,4-oxadiazol-2-yl)methyl methanesulfonate | HCID 86706759 | — |
| Product | (S)-1-(2-(5-((Dimethylamino)methyl)-1,3,4-oxadiazol-2-yl)pyrrolidin-1-yl)-2,2-difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)ethanone | HCID 86706760 | — |
Reaction Steps
The procedure of Example 6 was repeated, except that the compound obtained in Example 3-(5) was replaced by the compound obtained in Example 9-(6); this gave the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181229B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-3bf47a1fa0be4c668eba9c32286af543 |
| Source note | uspto-grants-2015_11 |