Hydroxyamine hydrochloride → 2-(3,4-Dimethoxyphenoxy)-N'-hydroxyacetoimidamide

Participants

Role	Name	HCID	Charge
Reactant	Hydroxyamine hydrochloride	HCID 443297	—
Reactant	3,4-Dimethoxyphenoxyacetonitrile	HCID 18991353	—
Solvent	Methanol--water (1/1)	HCID 22242641	—
Product	2-(3,4-Dimethoxyphenoxy)-N'-hydroxyacetoimidamide	HCID 86706761	—

Reaction Conditions

Temperature	100 °C

Reaction Steps

To a solution of 2-(3,4-dimethoxyphenoxy)acetonitrile (3.8 g) in MeOH—H2O (1:1), hydroxyamine hydrochloride was added and the mixture was stirred at 100° C. for 3 hours. After distilling off the solvent under reduced pressure, the residue was recovered by filtration and washed with water and hexane to give a crude form of the titled compound (4.9 g).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09181229B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-9ca000f3a7e144bdbd9b052e1308891e
Source note	uspto-grants-2015_11