反应详情

To a CHCl3 (20 ml) solution of the compound (1.0 g) obtained in Example 12-(1) and (S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid (1.0 g), WSC.HCl (1.0 g) was added and the mixture was stirred at room temperature for 4 hours. Water was added, followed by extraction with CHCl3. After distilling off the solvent under reduced pressure, the residue was dissolved in toluene (20 ml), followed by refluxing for 2 hours. The solvent was distilled off under reduced pressure and the residue was purified by silica gel chromatography (AcOEt/hexane) to give the titled compound (190 mg).

1. extractionfollowed by extraction with CHCl3
2. distillationAfter distilling off the solvent under reduced pressure
3. dissolutionthe residue was dissolved in toluene (20 ml)
4. temperatureby refluxing for 2 hours
5. distillationThe solvent was distilled off under reduced pressure
6. customthe residue was purified by silica gel chromatography (AcOEt/hexane)