Trifluoroacetic acid → (S)-5-((3,4-Dimethoxyphenoxy)methyl)-1-methyl-3-(pyrrolidin-2-yl)-1H-pyrazole

Participants

Reaction Steps

To a CHCl3 (1.0 mL) solution of the compound (365 mg) obtained in Example 13-(2), TFA (5.0 mL) was added at 0° C. and the mixture was stirred at room temperature for 2 hours. After concentrating the reaction mixture, saturated aqueous sodium bicarbonate (50 mL) was added and the organic layer extracted with CHCl3 (50 mL×2) was dried (Na2SO4), filtered and concentrated to give the titled compound (283 mg, pale brown oil.)

Provenance & Evidence