反应详情

To a CHCl3 (1.0 mL) solution of the compound (365 mg) obtained in Example 13-(2), TFA (5.0 mL) was added at 0° C. and the mixture was stirred at room temperature for 2 hours. After concentrating the reaction mixture, saturated aqueous sodium bicarbonate (50 mL) was added and the organic layer extracted with CHCl3 (50 mL×2) was dried (Na2SO4), filtered and concentrated to give the titled compound (283 mg, pale brown oil.)

1. concentrationAfter concentrating the reaction mixture, saturated aqueous sodium bicarbonate (50 mL)
2. additionwas added
3. extractionthe organic layer extracted with CHCl3 (50 mL×2)
4. dry with materialwas dried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated