反应详情

A solution of NaOH 1N (7.8 ml, 7.83 mmol) was added to a methanolic solution (40 ml) of (S) methyl 2-[2-(3,5-dimethylphenyl)acetamido]-3-phenyl-propanoate (635 mg, 1.95 mmol) and the reaction mixture was stirred for 1 h at rt, then concentrated under reduced pressure and residue diluted with H2O (40 ml) and HCl 1N to obtain a pH value equal to 2. The crude organic product was extracted with ethyl acetate (3×40 ml) and the organic phase was dried with anhydrous Na2SO4. The solvent was removed under reduced pressure to afford (S) 2-[2-(3,5-dimethylphenyl)acetamido]-3-phenyl-propionic acid as white solid with nearly quantitative yield.

1. concentrationconcentrated under reduced pressure and residue
2. additiondiluted with H2O (40 ml) and HCl 1N
3. customto obtain a pH value equal to 2
4. extractionThe crude organic product was extracted with ethyl acetate (3×40 ml)
5. dry with materialthe organic phase was dried with anhydrous Na2SO4
6. customThe solvent was removed under reduced pressure