Sodium Hydroxide → 2-[2-(3,5-Dimethylphenyl)acetamido]-3-phenyl-propionic acid

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Reaction Steps

A solution of NaOH 1N (7.8 ml, 7.83 mmol) was added to a methanolic solution (40 ml) of (S) methyl 2-[2-(3,5-dimethylphenyl)acetamido]-3-phenyl-propanoate (635 mg, 1.95 mmol) and the reaction mixture was stirred for 1 h at rt, then concentrated under reduced pressure and residue diluted with H2O (40 ml) and HCl 1N to obtain a pH value equal to 2. The crude organic product was extracted with ethyl acetate (3×40 ml) and the organic phase was dried with anhydrous Na2SO4. The solvent was removed under reduced pressure to afford (S) 2-[2-(3,5-dimethylphenyl)acetamido]-3-phenyl-propionic acid as white solid with nearly quantitative yield.

Provenance & Evidence