Hydrochloric Acid → HCID 178478531, compound

HRID 710239Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:12][N:11]=[C:10]([C:13]3[CH:18]=[CH:17][C:16]([CH:19]4[O:24][CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20]4)=[CH:15][CH:14]=3)[CH:9]=2)=[CH:4][CH:3]=1.Cl>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:12][N:11]=[C:10]([C:13]3[CH:14]=[CH:15][C:16]([CH:19]4[O:24][CH2:23][CH2:22][NH:21][CH2:20]4)=[CH:17][CH:18]=3)[CH:9]=2)=[CH:4][CH:3]=1

Participants

Conditions

Temperature: 60 °C

Procedure

tert-Butyl 2-(4-(5-(4-chlorophenyl)-1H-pyrazol-3-yl)phenyl)morpholine-4-carboxylate (180 mg, 0.41 mmol) was dissolved in dioxane (5.5 ml) and a solution of HCl in dioxane (4M, 1.53 ml, 6.15 mmol) was added. The reaction mixture was stirred for 2 h at 60° C. and overnight at room temperature. The solid was filtered off, washed with ether and dried in vacuo to afford 2-(4-(5-(4-chlorophenyl)-1H-pyrazol-3-yl)phenyl)morpholine hydrochloride (131 mg, 85%) as a white solid. MS (ISP): 340.1 ([{35Cl}M+H]+), 342.1 ([{37Cl}M+H]+).

Workup

filtrationThe solid was filtered off
washwashed with ether
customdried in vacuo

Sources & evidence

ORD record: ord-18f97755166242048c188138e1f64a91
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09181230B2

Reaction notes

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