Hydrochloric Acid → HCID 178478948, compound

HRID 710249Notes

Reaction equation

HRID 710249 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:12][N:11]=[C:10]([C:13]3[CH:18]=[CH:17][C:16]([C@@H:19]4[O:24][CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20]4)=[CH:15][CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1.[ClH:32].CCOCC>O1CCOCC1>[ClH:32].[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:12][N:11]=[C:10]([C:13]3[CH:14]=[CH:15][C:16]([C@@H:19]4[O:24][CH2:23][CH2:22][NH:21][CH2:20]4)=[CH:17][CH:18]=3)[N:9]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 178452467HCID 178452467, compound

Product 1

HCID 178478948HCID 178478948, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Conditions

Temperature
60 °C

Procedure

(S)-tert-Butyl 2-(4-(5-(4-fluorophenyl)-1H-1,2,4-triazol-3-yl)phenyl)morpholine-4-carboxylate (28 mg, 0.066 mmol) was dissolved in dioxane (0.5 ml) and a solution of HCl in dioxane (4M, 0.2 ml, 0.79 mmol) was added. The reaction mixture was stirred at 60° C. for 2 h. After cooling ether (2 ml) was added and the solid was filtered off. It was washed with ether and dried in vacuo to afford (S)-2-(4-(5-(4-fluorophenyl)-1H-1,2,4-triazol-3-yl)phenyl)morpholine hydrochloride (26 mg, 99%) as a white solid. MS (ISP): 325.2 ([M+H]+).

Workup

  1. additionwas added
  2. filtrationthe solid was filtered off
  3. washIt was washed with ether
  4. customdried in vacuo

Sources & evidence

ORD record
ord-4e1647edf412476ab07d652ad8745ac9
Source dataset
uspto-grants-2015_11
Patent number
US09181230B2

Reaction notes

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