反应详情

温度

-78 °C

n-Butyllithium 1.6 M in hexane (1.63 ml, 2.61 mmol) was diluted with tetrahydrofuran (2 ml) and cooled to −78° C. Acetonitrile (107 mg, 0.137 ml, 2.61 mmol) was added dropwise and stirring was continuing for 1 hour. (S)-tert-butyl 2-(4-(methoxycarbonyl)phenyl)morpholine-4-carboxylate (420 mg, 1.31 mmol) dissolved in tetrahydrofuran was slowly added to the white slurry over a 10 min period. After 3 hours, the reaction was quenched by addition of saturated ammonium chloride solution (5 ml) and extracted with diethyl ether (10 ml). The organic layer was dried over MgSO4 and evaporated.

1. additionwas slowly added to the white slurry over a 10 min period
2. waitAfter 3 hours
3. customthe reaction was quenched by addition of saturated ammonium chloride solution (5 ml)
4. extractionextracted with diethyl ether (10 ml)
5. dry with materialThe organic layer was dried over MgSO4
6. customevaporated