反应详情

温度

60 °C

(S)-tert-Butyl 2-(9H-pyrido[2,3-b]indol-6-yl)morpholine-4-carboxylate (22 mg, 0.062 mmol) was dissolved in dioxane (0.5 ml) and a solution of HCl in dioxane (4M, 0.19 ml, 0.75 mmol) was added. The reaction mixture was stirred for 2 h at 60° C. After cooling ether (2 ml) was added and the solid was filtered off. It was washed with ether and dried in vacuo to afford (S)-2-(9H-pyrido[2,3-b]indol-6-yl)morpholine hydrochloride (17 mg, 94%) as a light yellow solid. MS (ISP): 254.2 ([M+H]+).

1. additionwas added
2. filtrationthe solid was filtered off
3. washIt was washed with ether
4. customdried in vacuo