tert-Butyl-5-(4-(6-methoxy-3-(3,4,5-trimethoxybenzoyl)-1H-indol-1-ylsulfonyl)phenethyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate → 2-Amino-2-(3-1-admantanyl-4-isopropoxyphenethyl)propane-1,3-diol

Participants

Reaction Steps

When the product of Step C was substituted for tert-butyl-5-(4-(6-methoxy-3-(3,4,5-trimethoxybenzoyl)-1H-indol-1-ylsulfonyl)-phenethyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate in Example 13, Step F, the similar process afforded the title compound in 67% yield, as a creamy paste. 1H-NMR (CDCl3) 1.28 (d, 6H, J=6 Hz); 1.68 (s, 6H); 1.82-1.88 (m, 2H); 1.97 (s, 3H); 2.02 (s, 6H); 2.47-2.54 (m, 2H); 3.61 (d, 2H, J=12.1 Hz); 3.68 (d, 2H, J=12.1 Hz); 4.48-4.57 (m, 1H); 6.68 (d, 1H, J=8.4 Hz); 6.88 (dd, 1H, J=8.29, 2.1 Hz); 6.94 (d, 1H, J=2.14 Hz).

Provenance & Evidence