tert-Butyl 2,2-dimethyl-5-((4-octylphenylamino)methyl)-1,3-dioxan-5-ylcarbamate → HCID 46195743, compound

HRID 710491Notes

Reaction equation

HRID 710491 reaction equation
CC1(C)[O:7][CH2:6][C:5]([NH:28]C(=O)OC(C)(C)C)([CH2:8][N:9]2[CH2:15][CH2:14][C:13]3[CH:16]=[C:17]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH:18]=[CH:19][C:12]=3[CH2:11][CH2:10]2)[CH2:4][O:3]1.CC1(C)OCC(NC(=O)OC(C)(C)C)(CNC2C=CC(CCCCCCCC)=CC=2)CO1>>[NH2:28][C:5]([CH2:8][N:9]1[CH2:15][CH2:14][C:13]2[CH:16]=[C:17]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH:18]=[CH:19][C:12]=2[CH2:11][CH2:10]1)([CH2:6][OH:7])[CH2:4][OH:3]

Participants

3

Reactant 2

HCID 66726563tert-Butyl 2,2-dimethyl-5-((4-octylphenylamino)methyl)-1,3-dioxan-5-ylcarbamateHCID 86661820HCID 86661820, compound

Product 1

HCID 46195743HCID 46195743, compoundYield 48%

Procedure

When the product of Step F was substituted for tert-butyl 2,2-dimethyl-5-((4-octylphenylamino)methyl)-1,3-dioxan-5-yl-carbamate in Example 1, Step B, the identical process afforded the title compound in 48% yield., as creamy paste. 1H-NMR (CDCl3) 0.87 (tr, 3H, J=6.93 Hz); 1.12-1.28 (m, 12H); 2.5 (tr, 2H, J=7.77 Hz); 2.59 (s, 2H); 2.76-2.83 (m, 8H); 3.52 (s, 4H); 6.78-6.94 (m, 3H).

Sources & evidence

ORD record
ord-e6601e2b50bf492580cd06e4982280e2
Source dataset
uspto-grants-2015_11
Patent number
US09181182B2

Reaction notes

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