Benzylamine → HCID 178420321, compound

HRID 710499Notes

Reaction equation

HRID 710499 reaction equation
O1[CH:5]=[N:4][N:3]=[C:2]1[C:6]1[CH:14]=[CH:13][C:9]2[N:10]=[CH:11][NH:12][C:8]=2[CH:7]=1.[CH2:15]([NH2:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH2:15]([N:22]1[CH:5]=[N:4][N:3]=[C:2]1[C:6]1[CH:14]=[CH:13][C:9]2[NH:10][CH:11]=[N:12][C:8]=2[CH:7]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 58433284HCID 58433284, compound

Product 1

HCID 178420321HCID 178420321, compound

Procedure

The compound was synthesized starting from 5-(1,3,4-oxadiazol-2-yl)benzimidazole (186 mg, 1 mmol) and benzylamine (0.5 ml) as described above; yield: 0.072 g (26.2%); MS m/z: 276.5 [M+H]+; 1H-NMR (DMSO d6, 400 MHz): δ 5.39 (s, 2H); 6.99-7.01 (m, 2H); 7.20-7.29 (m, 3H); 7.63 (dd, 1H, 4J=1.7 Hz, 3J=8.7 Hz); 7.83 (d, 1H, 3J=8.7 Hz); 7.93 (br s, 1H); 8.79 (s, 1H); 9.09 (s, 1H); HPLC (METHOD [A]): rt 7.81 min (100%)

Workup

  1. customThe compound was synthesized
  2. customrt 7.81 min (100%)

Sources & evidence

ORD record
ord-1ea213e7683440a0afd9deb4089a2552
Source dataset
uspto-grants-2015_11
Patent number
US09181233B2

Reaction notes

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